REFERENCES

¹ Field trial comparing PPS with the combination PPS + NAG. Data on file.

² Laboratory studies of the anti-inflammatory activity of Pentosan + Glucosamine. Data on file.

³ Heinecke L.F., et al. Inhibition of prostaglandin E2 production in equine chondrocytes by PPS and NAG combinations. Poster 404 presented at ACVIM Forum June 9-12 2010, Anaheim California.

⁴ Shikhman AR et al. (2009) Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes. Osteoarthritis Cartilage 17(8):1022-1028.

⁵ Grevenstein J, et al. (1991) Cartilage changes in rats induced by papain and the influence of treatment with N-acetylglucosamine. Acta Orhop. Belg. 57, 157-61.  

⁶ TJ Koenig et al. The relationship between synovial fluid and cartilage chondroitin sulfate-846 epitope in a model of experimentally induced osteoarthritis in horses treated intravenously with Pentosan Polysulfate, N’Aceyl Glucosamine and Sodium Hyaluranon. Poster CS846 presented at  ACVS Veterinary Symposium November 3-5, Chicago Illinois.