COMPOSITION

Pentosan polysulfate sodium 100mg/mL

ACTIONS

Pentosan 100 contains sodium pentosan polysulfate which stimulates joint healing and repair, reversing the effects of osteoarthritis.
Pentosan polysulfate sodium possesses anti-inflammatory, anti-arthritic and chondroprotective properties. These beneficial effects arise from direct anti-inflammatory activity; inhibition of neutrophil migration into joints; stimulation of hyaluronic acid synthesis by synovial fibroblasts which results in a marked increase in synovial fluid volume and viscosity; stimulation of chondrocytes, and the biosynthesis of proteoglycans; and a strong fibrinolytic activity which improves the circulation in subchondral bone and periarticular structures.
Pentosan 100 is a semi-synthetic polysaccharide polymer which possesses anti-inflammatory, anti-arthritic and chondroprotective properties.

INDICATIONS

To aid in the treatment of non-infectious joint diseases in dogs, including osteoarthritis, especially in conditions affecting multiple joints; osteochondrosis dissecans; traumatic joint and periarticular inflammation in working and racing dogs.

DOSAGE AND ADMINISTRATION

Dosage Regime : 3 mg/kg by subcutaneous or intramuscular injection on four occasions with an interval of five to seven days between injections.  After the initial course of 4 injections, single injections may be repeated every 2 - 12 weeks as required for an extended period.

PRESENTATION

20ml sterile glass multidose vial

STORAGE

Store below 30°C (Room Temperature) Do not freeze. Protect from light.

AVAILABILITY

S4 - By Veterinary Prescription (APVMA 51175 Registered Name : Pentosan 100 Injection

WARNINGS

Contraindications : Pentosan 100 should not be given to dogs with clotting defects, traumatic haemorrhage, infection, renal or hepatic failure, and care should be taken within two days of surgery to ensure that any haemorrhage has ceased.